Abstract
p-Aminobenzoic acid was found to have a bactericidal action against Pseudomonas aeruginosa and Enterobacter cloacae. This action was not the result of a reduction in pH. An open porin strain of P. aeruginosa was more sensitive to p-aminobenzoic acid than the mother strain, indicating uptake via the outer membrane porin protein. Subinhibitory concentrations of a combination of p-aminobenzoic acid with dibromopropamidine isethionate were shown to have synergistic antibacterial activity against P. aeruginosa. Bacterial uptakes of the antibacterials determined by an HPLC assay method combined with dry cell weight determinations indicated that enhancement of activity of the combination was related to the fact that both compounds increase the bacterial uptake of the other. P. aeruginosa cells grown in the presence of subinhibitory concentrations of p-aminoenzoic acid sustained damage which made the cells more sensitive to the action of both benzalkonium chloride and EDTA and to lysis by lysozyme plus EDTA. These cells also exhibited lysis when treated with lysozyme alone indicating the p-aminobenzoic acid causes damage to the outer membrane. Folinic acid was found to block the antibacterial activity of p-aminobenzoic acid and to increase bacterial resistance to benzalkonium chloride and EDTA.
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