Abstract

Investigation of susceptible gas station workers to neurological disorders based on evidence of catechol -O- methyltransferase (COMT) gene expression alters

Highlights

  • Gasoline is a mixture of over 200 petroleum-derived chemicals and few synthetic products that are added to improve fuel performance [1,2,3,4]

  • Expression of the COMT gene was evaluated in Peripheral blood mononuclear cells (PBMC) of gas station attendants and control groups PBMC (Figure 1)

  • There was a considerable difference in gene expression rate between gas station attendants and control groups, COMT enzyme gene in PBMC of gas station attendants cases that showed a significant over expression compared to their counterparts in control groups

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Summary

Introduction

Gasoline is a mixture of over 200 petroleum-derived chemicals and few synthetic products that are added to improve fuel performance [1,2,3,4]. Benzene and many more compounds than just the better known BTEX (toluene, xylenes, and ethyl benzene) are the most important hazardous components of the gasoline. These aromatics are transmitted to humans by smell . The workers who had been working at gas station and industries that depend on gasoline exposed to the dangers of aromatic compounds liberated from gasoline fuel. When people fill their car with gasoline is the most common way they are exposed to benzene and other volatile aromatic hydrocarbons. S-COMT is thought to be mainly responsible for the elimination of biologically active or toxic, exogenous, catechols acting as an enzymatic detoxifying barrier between the blood and other tissues [13,14,15]

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