Investigation of Some Trace Elements levels & Antioxidants in Patients with Thalassemia Major and Sickle Cell AnemiaThalassemia in South of Iraq

Abstract

Back ground: Thalassemia major) THM( is the most common single gene disorder. It is a hereditary blooddisease characterized by reduced or absent production of beta globin chains. For the patients with SCA-Thal,they have two mutations (sickle cell anemia and thalassemia). The ratio of minerals and trace elements in thepatients’ blood played an important role in many biological processes. This study aims to measure the levelof seven elements, Fe, Mn, Ca+2, Mg, P, Cr, Co and three another antioxidant element (Zn, Cu &Se) in theblood of THM and SAC-thal patients.Results: In THM and SCA-Thal patients, antioxidant elements (Cu, Zn & Se), showed highly significantbehaviour when compared to each other and with the control group as total patient population, and as (total,male and female) numbers. In thalassemia patients, Fe, P & Co also showed highly significant behaviour,while Ca + 2 behaviour was not significant for male numbers only. Elemental Mg & Cr, demonstratedinsignificant behaviours. In SCA-Thal patients, Mn & Ca + 2 showed highly significant behaviour, while,Fe showed a non-significant behaviour relative to male numbers only, and Mg, P, Cr & Co showed nonsignificant behaviour.Conclusion: The study revealed the similarity of antioxidant elements behaviour in both diseases, as well asthe statistical behaviour of all elements when compared with the control group for these diseases.