Abstract
The aim of this work was a comparative study of the amount of antimicrobial peptides—human neutrophil peptides—defensins (HNP), hepcidin, bactericidal/permeability-increasing protein (BPI), and endotoxin in β-thalassemia. Blood samples of 135 patients with thalassemia were investigated. All patients were divided into 3 groups. The first group included patients with heterozygous form (n = 45). The second group consisted of patients with homozygous form before splenectomy (n = 45). The third group included patients with homozygous form after splenectomy (n = 45). The age of patients varied from 2 to 18 years. Biochemical [unconjugated and conjugated bilirubin, alkaline phosphatase, hemoglobin, ferritin, aspartate transaminase (AST), alanine transaminase (ALT), mean corpuscular volume (MCV)] and immune (IgA, IgM, IgG, phagocytic activity) parameters were defined. Obtained results suggest that increased levels of endogenous antimicrobial peptides are associated with the development of the infectious process and reflect the dynamics of changes in biochemical parameters and immune status.
Highlights
The aim of this work was a comparative study of the amount of antimicrobial peptides - human neutrophil peptides - defensins (HNP), hepcidin, bactericidal/permeability-increasing protein (BPI), and endotoxin in β-thalassemia
The aim of this work was a comparative study of the amount of antimicrobial peptides - defensin, hepcidin, protein that increases the permeability of the membranes (BPI) and endotoxin in β-thalassemia, as well as analysis of the relationship between biochemical indicators, quantity of iron and level of secretion of antimicrobial peptides
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Summary
Arif Mustafa Efendiyev, Gulnara Ibrahim Azizova, Arzu Ramiz Dadashova biochemical changes in the immune status of patients with β-thalassemia, but the data on the study of the level of secretion of endogenous antimicrobial peptides in this disease are negligible. Human body has complex mechanisms of defence against exogenous pathogens and internal risks (malignant growth). Research Laboratory of Biochemistry Department, Azerbaijan Medical University, Baku, Azerbaijan. Defence strategy is based on the presence of a two-stage protection: non-specific (innate immune system) and specific (adaptive immune system).[5]
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