Investigation of Some Angiogenic Factors Related to Aging in Brown and White Adipose Tissues of Rats

Abstract

Aging is a biological phenomenon in which life force decreases, there is an increase in dysfunction, and activities at the level of tissue and cell with insufficient response to changes in internal and external environments decrease. In biological aging, there are deficiencies in the cell level, the cells and tissues are prevented from feeding with enough oxygen and hypoxic conditions can occur. Due to the loss of function in living organisms as a result of aging, the failure of the organelles to perform their functions may lead to the emergence of oxygen deficiency conditions in the tissues. The most common feature of aging is the change of physiological functions over time. Especially when oxygen deficiency appears in the tissues, the number of red blood cells increases, hormones and angiogenic factors releasing increase. Hypoxia may also occur in tissues due to environmental factors, obesity and various circulatory insufficiency, and the organism may activate angiogenic factors in response to this. Adequate oxygen must be provided for the normal functioning of the tissues. In the case of oxygen deficiency (hypoxia), matrix metallo proteinase, vascular endothelial growth factor, tumor necrosis factor, interleukin may play role such as angiogenic factors. In this study, the levels of vascular endothelial growth factor (VEGF), matrix metalloproteinase‐II, hypoxia‐inducible factor‐1α, adrenomedullin were investigated in 6 months and 24 months old rats. The vascularity function of the tissues is very important. Vein formation is required in both normal functional tissues and in tissues that are in neoplastic formation. Therefore, in this study, we investigated the angiogenic factors in rats' brown and white adipose tissue in cases by aging. In the study, 24 rats were divided into two groups; 12, 6‐month old young and 12, 24‐month‐old rats were evaluated as elderly group. In the study, angiogenic factors increased in the white adipose tissues of the elderly animals, whereas it was found that there was a greater increase in the brown adipose tissue that plays a role in the thermogenesis event in young rats. Decreasing physical activity in elderly animals and increased activity in white adipose tissue resulted in a significant increase in the weight of aged rats. Angiogenic factors play an important role in maintaining the oxygen demand of the organism in elderly animals, while it may cause an increase in the expanding of the white adipose tissue, which is effective on weight gain, which may lead to obesity.Support or Funding InformationThis research was funded by Inonu University, Department of Scientific Research Projects Project No: FYL‐2017‐748).This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.