Abstract
The blend films were fabricated via blending sodium hyaluronate (SH) and Konjac glucomannan (KGM). Lactic acid was applied as modifier and the mixture of Ammonia and anhydrous alcohol as cross-linker. The influencing factors were analyzed via the orthogonal experiment L16(4,5). It was shown that the water absorption of the blend films was around 151%~608%. Tensile strength and elongation of the blend film samples reached about 11.3~20.7MPa and 10.8~20.2% respectively. The degradation rate declined obviously compared with the simple use of the SH. XRD and IR spectra indicated that crystallinity of the blend films was enhanced slightly after cross-linking. The blend films were co-cultured with bone mesenchymal stem cells. It was demonstrated that the films could support the growth of cells and were non-toxicity and good biocompatibility.
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