Abstract
1. 1. Extracts of roots, seeds and fruits of seventeen plant species belonging to Family Cucurbitaceae were examined for the ability to inhibit protein synthesis in rabbit reticulocyte lysate and induce mid-term abortion in mice. 2. 2. Out of the 22 tissue extracts examined, 16 were found to inhibit protein synthesis by >90%, three caused 65–85% inhibition and 3 caused <25% inhibition. 3. 3. In general, there was a close correlation between protein synthesis inhibiting activity and mid-term abortifacient activity of the tissue extracts. 4. 4. SDS-PAGE of the tissue extracts revealed the presence of a Coomassie Blue-stainable band with a mol. wt of ca 30,000. The data suggest that this band is responsible for the protein synthesis inhibiting and mid-term abortifacient activities.
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