INVESTIGATION OF RELATIONSHIP BETWEEN rs1800796 VARIANTS OF INTERLEUKINE-6 GENE AND CORONARY ARTERY DISEASE

Abstract

The most important characteristic of coronary artery disease, which is one of the most common and most important health problems today, is that it can lead to life-threatening myocardial infarction in advanced stages. It is more important to take protective preventions by knowing the risk factors that cause the disease rather than the treatment of this disease. This study was performed on coronary artery disease (CAD) to determine the frequency of the interleukin-6 gene (IL-6) 572G/C polymorphism and to examine the role of this polymorphism in CAD development. Genomic DNA obtained from 185 persons (103 CAD patients, 82 controls) was used in the study. IL-6 572 G/C polymorphism genotypes were determined using PCR, RFLP and electrophoresis. The results were statistically analyzed. The frequencies of 572 G/C genotypes, in controls GG 83%, GC 17%, CC 0% and in CAD patients GG 72% , GC 28% and CC 0% were found. There was no significant difference between the control group and the patient groups in genotype frequencies. It was determined that GG genotype frequency increases significantly in patients according to control group. Based on the results of our study, we may suggest that there is no association between CAD and IL-6 572G / C polymorphism.