Abstract
Publisher Summary Coenzyme Q (CoQ) is not only present in all cells and membranes of the eukaryotic cells, but it is also synthesized and broken down in all cells. The lipid is a structural component, and its major part is associated with the membrane. Unlike cholesterol, CoQ itself is not serving as substrate for other products, its metabolism is strictly regulated, and variations in amount are limited. Coenzyme Q and a large portion of drugs are not soluble in water, and the food containing the substance has to be prepared continuously to avoid breakdown processes. There is a practical procedure to perform the preparation of diet, which has proved to be efficient, time saving, inexpensive, and functional. Coenzyme Q has a high turnover, indicating an extensive breakdown of the lipid. The half-life is somewhat different in various organs of rat and, it varies between 49 and 125 h. Coenzyme Q breakdown products were analyzed in urine, feces, and some tissues of rat and rabbit after administration of CoQ7 and CoQ10, and a number of metabolites were identified by chemical synthesis and gas chromatography. It is also possible to prepare membranes with an increased concentration of the specific lipid and test lipid interactions by use of a mixture during reconstruction. Such experiments are of interest in studying the influence of membrane structure and composition on various functions.
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