Abstract
DNA alkylation: The reactivity and selectivity of DNA-alkylating duocarmycin analogues were determined by direct ESI-FTICRMS (negative-ion mode) measurements. The high efficiency of a new seco drug for the alkylation of duplex DNA has been determined in this way for the first time (picture: drug bound covalently to an oligodeoxynucleotide). The corresponding, less toxic prodrug and the enantiomer of the seco drug show, in contrast, only a very low alkylation tendency.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
