Investigation of prevalence and risk factors of H-type hypertension among middle-aged and elderly people in Beijing community

Abstract

Objective To investigate the prevalence and risk factors of H-type hypertension among middle-aged and elderly people in community. Methods A cross-sectional study by recruiting 1 458 middle-aged and elderly people from a cohort of the Beijing Longitudinal Study of Aging in 2009 was conducted. All participants were asked to complete a standardized questionnaire, physical examination and laboratory examinations. Hyperhomocysteinemia was defined as homocysteine (Hcy) > 15 μmol/L, and H-type hypertension was defined as having hypertension and hyperhomocysteinemia simultaneously. The prevalence of H-type hypertension was estimated by using the results of 2000 population census to weight the data. Multivariate Logistic regression analysis was preformed to estimate the associated factors of H-type hypertension. Results The age was (69.48 ± 8.09) years, and the distribution of Hcy was skewed with the median of 16.56 μmol/L. After weight, the prevalence of hyperhomocysteinemia was 57.20% (834/1 458), and the prevalence of H-type hypertension was 35.32% (515/1 458), accounting for 59.47% (515/866) in patients with hypertension. The ageing, male, hyperuricemia, estimated glomerular filtration rate (eGFR) and insufficiency of fishes/shrimps were independent risk factors of H-type hypertension (OR= 2.30, 1.04, 1.02, 0.95 and 0.67; 95% CI 1.54-3.44, 1.02-1.06, 1.04-1.06, 0.94-0.97 and 0.46-0.97; P<0.01 or <0.05). Conclusions The proportion of H-type hypertension is high in the middle-aged and elderly people in community. Lowering uric acid, protection of renal function and intake sufficient fishes and shrimps might prevent and control H-type hypertension. Key words: Hypertension; Middle aged; Aged; Prevalence; Risk factors