Abstract
Diabetes mellitus type 2 (DM2) is a metabolic disease that involves complex multifactorial genetic and environmental factors [1]. Studies on the molecular genetics has suggested that many genes may be important in susceptibility to DM26. Recently, large-scale studies such as genome-wide associations studies (GWAS) have shown several important genes associated with T2DM. Among these genes, one of the most strongly associated with the disease is TCF7L2. This gene has many polymorphisms described, however the majority of studies indicate variants rs7903146 and rs12255372 as the most important within this gene.
Highlights
Diabetes mellitus type 2 (DM2) is a metabolic disease that involves complex multifactorial genetic and environmental factors [1]
Studies show that carriers of the risk allele exhibit increased levels of some inflammatory markers such as C-reactive protein (CRP) and Hb1Ac [3]
No significant associations were detected between the variants analyzed and the biochemical variables
Summary
Investigation of polymorphisms rs7903146 and rs12255372 in the TCF7L2 gene in biochemical markers of severity of type 2 diabetes mellitus (T2DM) in a sample of adults with T2DM. Simone Morelo Dal Bosco*, Cristiane dos santos Costa, Adriana Regina Bitello, Crislene Sippel, Rafaela Bastian, Maria Wollinger, Julio Dessoy, Olívia Bouchacourt, Rosangela Leipinitz, Veronica Contini, Claudete Rempel, Julia Genro. From 5th Congress of the Brazilian Biotechnology Society (SBBIOTEC) Florianópolis, Brazil. From 5th Congress of the Brazilian Biotechnology Society (SBBIOTEC) Florianópolis, Brazil. 10-14 November 2013
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