Investigation of Placental Modifications in Patients with Preeclampsia: Examination using Light and Electron Microscopy

Abstract

Preeclampsia can have an effect on both the mother's health as well as the unborn child, and it only occurs during gestation and after delivery. Proteins in urine as well as high levels of blood pressure are two signs of this disease that advances swiftly. The study's goal was to look at the histology and to examine for ultrastructural alterations in the placentas of preeclampsia-affected pregnancies. Slices of paraffin were made from placenta specimens used for light microscopic analysis while an electron microscope with scanning technology was employed to produce and observe specimens for ultrastructural analysis. The syncytiotrophoblast layer nuclei were found to be arranged in many sprouts and lengthy anastomosing strands, according to light microscopic examinations. The foetal placental capillaries receded up to total absence as the villus connective tissue core gradually contracted. Endothelial degeneration and atheromatous changes were present in placental stem arteries, whereas endothelial degeneration, escalating fibrosis, and obliteration were seen in lower decidual arterioles. These results are compatible with a rise in fetoplacental vascular impedance, which was shown to be present when lacking end-diastolic flow velocity was established that it existed in the umbilical artery just before birth. The results clarify how this issue has interfered with the movement of nutrients and gas.