Abstract
Background: In this study, we aimed to determine PTX3 levels in hypertensive patients with nephropathy, retinopathy and stroke. Methods: This study is considering totally 135 patients including normotensives and newly diagnosed hypertensive and hypertensive with nephropathy, retinopathy and stroke. Blood samples were extracted to perform biochemical tests and PTX3 levels. Results: It is observed that PTX3 levels in the normotensive patients, isolated hypertensive patients and hypertensive patients have complication resulted with statistically differences (0.19 ± 0.15 ng/Ml, 37.15 ± 8.02 ng/Ml, 451.28 ± 244.39 ng/mL, p<0.00001). This arises from the differences between the PTX3 levels which belong the patient group has complication along with other groups and isolated hypertensive group along with normotensive group by the performed Post Hoc analyze. If the patients have complication are compared with each other, it is observed PTX3 level in the retinopathy group is statistically higher with reference to other groups (In retinopathy, neuropathy and nephropathy groups’ 710.90 ± 254.6 ng/mL, 408.14 ± 65.56 ng/mL, 253.61 ± 62.66 ng/mL, p<0.0001 respectively). It was established PTX3 levels in the complicated hypertensive patients is associated with BMI and LDL/HDL by the performed multivariate regression analysis (For BMI, LDL/HDL is respectively R square=0.085, F=5.84 and p=0.019 versus R square=0.153, F=5.61 and p=0.006). Conclusion: It is observed in the present study that in hypertensive patients with stroke and retinopathy and nephropathy, and isolated hypertensive, PTX3 levels are elevated. It is also found BMI and LDL/HDL is associated with PTX3 levels.
Highlights
Hypertension is one of the most common reasons around the world which lead to mortality and morbidity
Diagnosis and end organ damage severity and secondary disorders are crucial to detect the cardiovascular prognosis in the patients who suffer from the arterial hypertension [1,2]
Complete blood count (CBC) test, liver and kidney functions test, lipid profile, fasting blood glucose and pentraxin 3 (PTX3) levels were studied with the blood sample which is taken after 10 hours fasting at 08:00 am
Summary
Hypertension is one of the most common reasons around the world which lead to mortality and morbidity. Diagnosis and end organ damage severity and secondary disorders are crucial to detect the cardiovascular prognosis in the patients who suffer from the arterial hypertension [1,2]. Hypertensive end organ damage is an atherosclerosis which includes differentiation such as vascular and hemorrhagic stroke, retinopathy, cardiac disorder/myocardial infarction, heart failure, proteinuria and renal failure, stenos and aneurism [3]. Higher arterial blood pressure leads organ damages via hemodynamic load [4]. High arterial pressure load and a lot of factors which are associated with pathogenesis may influence the severity of the end organ damages [5]. The main reason of the vascular inflammation and cardiovascular disorders associated with hypertension could be the relationship between high blood pressure which leads mortality all around the world and atherosclerosis. We aimed to determine PTX3 levels in hypertensive patients with nephropathy, retinopathy and stroke
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