Abstract
Origanum compactum Benth. has been widely used in moroccan traditional medicine for various therapeutic treatments. Belonging to the same genus, O. onites was found to have marked analgesic and anti-inflammatory activities. The aim of this work is to evaluate theses pharmacological properties of the essential oil of O. compactum in order to provide a basis for the folkloric use of the plant. Aerial parts of plant were subjected to steam distillation, according to the French Pharmacopoeia. Male OF1 mice and male Wistar rats were used for these studies. The analgesic effect was done using Writhing test in mice and Tail-Flick test in rats. The mechanism investigation was evaluated employing an antagonism assay using naloxone, a specific antagonist of opiate receptors. Anti- inflammatory property has been studied using carrageenin and experimental trauma induced edema in rats. The essential oil of the aerial parts of Origanum compactum was found to exert central analgesic properties. Such a dose-dependent action was obtained against chemical and thermic stimuli, respectively, from the doses of 6.25 and 12.5 mg/kg and it was inhibited by a naloxone pretreatment, a specific morphinic antagonist compound. Significant and dose-dependent anti-inflammatory effects were observed on an acute inflammatory process from the dose of 100 mg/kg.
Highlights
Herbal remedies have been used for centuries for the treatment and management of various diseases
The results obtained with the reference substances, acetylsalicylic acid and morphine, show a significant and important protective effect, reducing the pain phenomena by more than 50%
The present results indicate that the essential oil of Origanum compactum exhibits central analgesic properties, since it exerted a significant and dosedependent protective effect on chemical and thermic painful stimuli, from the respective doses of 6.25 and 25 mg/kg i.p
Summary
Herbal remedies have been used for centuries for the treatment and management of various diseases. Herbal medication is a promising alternative to modern synthetic drugs because of their low side effects. They are considered safe and effective in the treatment of human diseases [1]. Several bioactive compounds are extracted of various medicinal plants. These products, belonging to different chemical families such as terpenoids, flavonoids, saponins, alkaloids phenolic acids and essential oils, have been identified as promising molecules in the treatment of inflammation and pain [2,3,4,5]. Essential oils, extracted from plants, are recognised as active and remarkable pharmaceutical substances due to their various biological properties. Antifungal, antiviral, antioxidant, anticancer, immunomodulatory, analgesic, antiinflammatory and other activities [6,7,8]
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