Abstract
BackgroundRespiratory infections caused by viruses affect the lower respiratory tract; these infections are severe in patients with underlying diseases and can even lead to death. Respiratory syncytial virus (RSV), one of the causative agents of respiratory viral infections, is the most common cause of pneumonia and bronchiolitis in children and adults.MethodsRespiratory specimens (nasopharyngeal aspirate, nasal swab, throat swab, etc.), which were sent to the Department of laboratory medicine from January 2012 to December 2018 for detection of respiratory viruses via real time reverse transcription PCR (Real time RT-PCR) were used in this study. RSV detected by real-time RT-PCR were analyzed on the basis of co-infection, sex and age of the patients, and year and month of sample collection.ResultsDuring the study period, we observed that the RSV detection rate was 12.8% (n = 1150/9010); the detection rate of RSV-A (7.1%) was higher than that of RSV-B (5.8%). The detection rate of RSV was the highest at 36.5% in December, and RSV-A and RSV-B were in vogue every year. Co-infection rate of RSVs was the highest in the patients over 80 years of age; RSVs showed the highest Co-infection with Rhinoviruses.ConclusionsDuring the study period, prevalence was different among the two subtypes of RSV, and the average age of RSV-B-positive patients was higher than that of RSV-A. Co-infection rate tended to increase every year. RSVs cause mild as well as severe infections. There are reports of serious clinical progress as RSVs cause overlapping infections with other viruses and increase the risk of secondary bacterial infections. Thus, further research on RSV should be done.
Highlights
Respiratory infections caused by viruses affect the lower respiratory tract; these infections are severe in patients with underlying diseases and can even lead to death
respiratory syncytial virus (RSV) is an RNA virus, which belongs to the genus Orthopneumovirus, and it is the most common cause of bronchiolitis and pneumonia in children under 1 year of age [3, 4]
Most children are infected with RSV at least once before the age of two [5], and RSV bronchiolitis in infants is a major reason for their hospitalization
Summary
Respiratory infections caused by viruses affect the lower respiratory tract; these infections are severe in patients with underlying diseases and can even lead to death. Respiratory syncytial virus (RSV), one of the causative agents of respiratory viral infections, is the most common cause of pneumonia and bronchiolitis in children and adults. RSV is an RNA virus, which belongs to the genus Orthopneumovirus, and it is the most common cause of bronchiolitis and pneumonia in children under 1 year of age [3, 4]. Most people infected with RSV recover within one to 2 weeks, but it causes pneumonia in in older or immunocompromised individuals, which requires hospitalization. Individuals with congenital heart defects, premature infants, children immediately after open heart surgery, and immunocompromised patients (such as bone marrow transplant or organ transplant patients), previously healthy children are severely affected by RSV infections [7, 8]. The most important treatment for acute bronchiolitis, mainly caused by the respiratory syncytial virus (RSV), is oxygen and hydration. The epidemiological and clinical characteristics of RSV-A and B infections differ [11]
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