Abstract
Objective To investigate mineral bone metabolic conditions of pre-dialysis patients with chronic kidney disease (CKD), and obtain useful information about the management and treatment of CKD. Methods The levels of serum calcium, phosphate, 25-HydroxyvitaminD[25(OH)VitD], and intact parathyroid hormone (iPTH) were compared. Then a correlation analysis was performed for 25(OH)VitD. Results Hypocalcemia, hyperphosphatemia, secondary hyperparathyroidism and inadequate of 25(OH)VitD appeared early in CKD2. Deficiency of 25(OH)VitD was widespread in CKD2~5. Multiple linear regression analysis showed that 25(OH)VitD was independently associated with adjusted level of calcium (P=0.002), application of calcium carbonate (P=0.038), and application of calcitriol (P=0.049) (R square=0.360, P=0.000). Conclusions Mineral bone disorder emerges early in CKD2. More attention should be paid to the management of 25(OH)VitD. Key words: Kidney diseases/ME; Minerals/ME; Vitamin D/ME
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