Investigation of medical intervention with fatal outcome: the impact of post-mortem CT and CT angiography.

Axel Heinemann,Hermann Vogel,Martin Heller,Klaus Püschel,Antonios Tzikas

doi:10.1007/s11547-015-0574-5

Axel Heinemann, Hermann Vogel + Show 3 more

Open Access

https://doi.org/10.1007/s11547-015-0574-5

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Abstract

Post-mortem computed tomography (PMCT) has been proven for its appropriateness to become an integral part of routine pre-autoptic forensic investigations either in the field of forensic investigation of fatal medical error or in hospital quality management. The autoptic investigation of unexpected and peri-interventional deaths can be usefully guided by post-mortem imaging which offers significant added value in the documentation of misplacement of medical devices before dissection with the risk of artificial relocation and the detection of iatrogenic air embolism. Post-mortem CT angiography (PMCTA) augments PMCT in the search for sources of hemorrhages and for the documentation of vascular patency and unimpaired perfusion after general and cardiovascular surgery or transvascular catheter-assisted interventions. Limitations of PMCT and PMCTA in medical error cases are method-related or time-dependent including artifacts by early post-mortem tissue change. Thromboembolic complications including pulmonary embolism, the differentiation of ante- and post-mortem coagulation and the detection of myocardial infarction remain areas with compromised diagnostic efficiency as compared to autopsy. Furthermore, extended survival periods after a complication in question impedes visualization of contrast agent extravasation at vascular leakage sites. PMCT and PMCTA contribute substantially for proving a correct interventional approach and guide forensic or clinical autopsy in the reconstruction of adverse medical events with fatal outcome. Post-mortem imaging could also assume a new role as an alternative in a clinicopathological setting if autopsy is not achievable when the probability in the individual case is acceptable to answer specific questions.

Highlights

During the last 10 years, post-mortem computed tomography (PMCT) has developed to become a tool for routine work in more and more institutes of forensic medicine across Europe and worldwide [1,2,3,4,5,6,7,8]
PMCT complements the internal examination of the body by being implemented in pre-autopsy routines while new techniques are under development for post-mortem application and the new subspecialty of forensic radiology is developing [9, 10]
200 hospital fatalities have been examined with multiphase post-mortem CT angiography (MPMCTA) after performance of PMCT according to reported standard methods [25]

Summary

Introduction

During the last 10 years, post-mortem computed tomography (PMCT) has developed to become a tool for routine work in more and more institutes of forensic medicine across Europe and worldwide [1,2,3,4,5,6,7,8]. PMCT complements the internal examination of the body by being implemented in pre-autopsy routines while new techniques are under development for post-mortem application and the new subspecialty of forensic radiology is developing [9, 10]. There is a rising number of reports about the advantages of post-mortem imaging in cases with fatal outcome after medical intervention [12,13,14,15,16,17,18]. Autopsy can be guided by PMCT in case of skeletal trauma and by typical features like fatal complications after medical treatment such as misplaced catheters, guidewires, tubes and drainages, sources of intervention- related hemorrhages and gas embolism

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