Abstract
Obstructive sleep apnea syndrome (OSAS) is a common disease of sleep disorder mainly due to chronic intermittent hypoxia caused by hypoxia-reoxygenation.Liver injury has become popular topic of target-organ damage with deep research.Clinical and animal studies indicate that OSAS style intermittent hypoxia can cause morphologic and function changes of liver and is related to morbidity of nonalcoholic fatty liver disease.The pathogenesis of liver injury may be lipid metabolism disorder,insulin resistance and oxidative stress and inflammation reaction caused by chronic intermittent hypoxia.This review focuses on studies of OSAS with liver injury and pathogenesis of it.It can provide experimental evidence and theoretical basis for the prevention and control of OSAS with liver damage and open up new strategies for the prevention and control of OSAS system damage. Key words: Obstructive sleep apnea syndrome; Chronic intermittent hypoxia; Liver injury; Nonalcoholic fatty liver disease
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