Investigation of magnetically controlled water intake behavior of Iron Oxide Impregnated Superparamagnetic Casein Nanoparticles (IOICNPs).

Anamika Singh,Anil Kumar Bajpai,Jaya Bajpai

doi:10.1186/s12951-014-0038-4

Abstract

Iron oxide impregnated casein nanoparticles (IOICNPs) were prepared by in-situ precipitation of iron oxide within the casein matrix. The resulting iron oxide impregnated casein nanoparticles (IOICNPs) were characterized by Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR), Vibrating sample magnetometer (VSM) and Raman spectroscopy. The FTIR analysis confirmed the impregnation of iron oxide into the casein matrix whereas XPS analysis indicated for complete oxidation of iron (II) to iron(III) as evident from the presence of the observed representative peaks of iron oxide. The nanoparticles were allowed to swell in phosphate buffer saline (PBS) and the influence of factors such as chemical composition of nanoparticles, pH and temperature of the swelling bath, and applied magnetic field was investigated on the water intake capacity of the nanoparticles. The prepared nanoparticles showed potential to function as a nanocarrier for possible applications in magnetically targeted delivery of anticancer drugs.

Highlights

The concept of magnetic drug targeting (MDT) entails retaining specially designed magnetic drug nanocarriers at a specific site in the body using an externally applied magnetic field
The present study aims at designing controllable size iron oxide impregnated casein nanoparticles (IOICNPs) by coprecipitation of iron salts within the casein nanoparticles matrix
The prepared matrix is composed of casein and glutaraldehyde which are hydrophilic biopolymer and crosslinker, respectively and their relative amounts in the CNPS are expected to affect extent of swelling and, the impregnation of iron oxide

Summary

Introduction

The concept of magnetic drug targeting (MDT) entails retaining specially designed magnetic drug nanocarriers at a specific site in the body using an externally applied magnetic field. (Step-III) In situ precipitation of iron oxide within the casein nanoparticles matrix to yield IOICNPs. Raman spectroscopy was used and the spectra were obtained in the range of 200–1800 cm−1.

Results

Conclusion