Abstract
Biocompatible magnetic poly (glycidyl methacrylate) microsphere is a novel nanocomposite with a myriad of promising bioapplications. Investigation of their characteristics by experimental analysis methods has also been carried out in the past. However, a survey of the magnetic anisotropy constant has not been mentioned and the influence of the poly (glycidyl methacrylate) polymer matrix on the Fe3O4 magnetite nanoparticles embedded inside has also not been discussed. Moreover, the accurate characterization of the magnetite nanoparticle size distribution remains challenging. In this paper, we present an effective approach was used to solve these problems. First of all, we combine both experiment and theory to estimate the effective magnetic anisotropy constant. Besides that, we implement an accurate method to determine magnetite nanoparticle size distribution in the magnetic poly (glycidyl methacrylate) microspheres composite nanomaterial.
Highlights
During the last decade, Fe3O4 magnetite nanoparticles (MNPs) have been used in large number of fields, such as water treatment [1, 2], image diagnosis (magnetic resonance imaging (MRI) contrast agent) [3], cancer therapy [4, 5], separating cells, and capturing proteins/ biomolecules [6]
The advantage of the poly (PGMA) is being hydrophilic, as epoxy groups can be modified to carry a variety of reactive functional groups like NH2, COOH, and SH, which can be conjugated with biomolecules [13], and stability in various biological media
X-Ray Diffraction. e results of the X-ray phase analysis on the formation of samples were confirmed by X-ray diffraction (RD), obtained with the D8 Advance– Bruckner diffraction meter (Germany), using CuK∝ radiation with λ 0.15406 nm in the range of 2 θ from 10° to 70° at room temperature (300 K)
Summary
Fe3O4 magnetite nanoparticles (MNPs) have been used in large number of fields, such as water treatment [1, 2], image diagnosis (magnetic resonance imaging (MRI) contrast agent) [3], cancer therapy (magnetic hyperthermia mediator, targeted drug, or gene delivery vehicle) [4, 5], separating cells, and capturing proteins/ biomolecules [6]. Erefore, the PGMA polymer microsphere embeds the MNPs showing great potential in nanomedicine, biotechnology, and molecular biology [14] This biocompatible polymer may interact with the surface atoms of Advances in Materials Science and Engineering the MNPs embedded inside and form a magnetically disordered layer or nonmagnetic layer [15]. As a result, it contributes to the influence on the particles size distribution and the magnetic anisotropy, which are the crucial parameters in numerous applications [16]. To the best knowledge of the authors, the magnetic anisotropy constant value, influence of PGMA polymer matrix to the MNPs, and the particle size distribution function determination of the MNPs inside the PGMA microspheres nanocomposite material are not studied so far. Using the fitting of experimental magnetization curve data to the Langevin function enables determination of the median particle size, the corresponding standard deviation, and the particle size distribution function of the MNPs embedded inside the M-PGMA microspheres
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