Abstract

Recently, we have demonstrated the magnetic field-enriched surface-enhanced resonance Raman spectroscopy (SERRS) of &beta;-hematin by using nanoparticles with iron oxide core and silver shell (Fe<sub>3</sub>O<sub>4</sub>@Ag) for the potential application in the early malaria diagnosis. In this study, we investigate the dependence of the magnetic field-enriched SERRS performance of &beta;-hematin on the different core and shell sizes of the Fe<sub>3</sub>O<sub>4</sub>@Ag nanoparticles. We note that the core and shell parameters are critical in the realization of the optimal magnetic field-enrich SERRS &beta;-hematin signal. These results are consistent with our simulations that will guide the optimization of the magnetic SERRS performance for the potential early diagnosis in the malaria disease.

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