Abstract
Objectives: Lipoprotein lipase (LPL) is a key enzyme of TG-rich lipoproteins metabolism. LPL deficiency (LPLD) is a rare mendelian cause of severe hypertriglyceridemia and chylomicronemia (CM). Recent data obtained with an ApoC-III ASO in LPLD support APOC3 as a key regulator of LPL-independent pathways of TG-rich lipoproteins metabolism. The aim of this study was to investigate gene expression profiles and lipoprotein characteristics in CM and a wide spectrum of LPL activity (0%, 50% and 100%).
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