Investigation of large granular lymphocytic leukemias: data from the laboratory of hematology at Nancy University Hospital, France

Abstract

to report on the diagnostic and therapeutic management of LGLL investigated in the university hospital at Nancy, France. retrospective (7 years) collection of clinical and biological data and patients' cohort analysis. Eight out of fifteen patients presented with neutropenia, including five profound neutropenia (neutrophils <500 ×109/L). Four patients had an infection. Two patients have rheumatoid arthritis and an associated Felty's syndrome, one a Sweet syndrome. Two also suffered from chronic Lymphocytic Leukemia, and one from a diffuse large B-cell lymphoma. Twelve patients had LGLL-T and 3 had a chronic LGLL-NK. Eleven out of twelve patients had a clonal LGLL-T when polymerase chain reaction assessed. No KIR clonality was sought among the 3 LGL-NK patients. Five patients out of fifteen received immunosuppressive treatment. Although using simple and robust investigations, our series demonstrates a high heterogeneity in LGLL detection and assessment.