Abstract
Abstract Some species of Lactobacillus have demonstrated beneficial health effects being applied in the production of food supplements. Thus, the incorporation of viable cells as encapsulated probiotics represents an essential condition to be considered in new strategies for the controlled release of microorganisms. Herein, the massive encapsulation of Lactobacillus paracasei is provided by the use of alternative electrospinning technique. Is spite of the high voltage required for the production of fibers, a high density of viable cells is observed into the polymeric electrospun web, allowing the controlled release at targeted pH (characteristic of Eudragit® L100 polymer support). The reported procedure circumvents typical drawbacks of degradation of microorganisms under adverse conditions (storage, package and low pH) and preserves its biologic action after complete release from polymer fibers.
Highlights
Some probiotic bacteria have positive physiological administration[17]
The morphology of L. paracasei, electrospun fibers of Eudragit® L100 (EDGT) and electrospun fibers with L. paracasei (EDGT-L.paracasei) were compared from Scanning Electron Microscopy (SEM) images, as shown in Figure 1 – the diameter was calculated from 25 different fibers per image
The electrospinning technique demonstrated to be a successful strategy applied in the encapsulation of L. paracasei by Eudragit® L100
Summary
Some probiotic bacteria have positive physiological administration[17]. The acidic environment (stomach/ bile salts) the creation of Lactobacillus spp. has been considered as a promising an anaerobic environment for probiotics growth received probiotic that confers health benefits to the host. Recent increased attention in the literature with promising strategies studies considered the use of Lactobacillus spp. in the to maintain the viability of cells until to reach the colon lumen. It has been reported that bioactive living cells, such as the Lactobacillus spp. present low bioavailability/ biofunctionality as a consequence of transport through the gastrointestinal tract, in the processing and/or prolonged storage[8,9]. The acidic medium can induce changes on bacterial membrane components, modifying and disturbing the peptidoglycan components, lipids, proteins and DNA in Gram-positive bacteria[10]
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