Abstract
Background: Polycystic ovarian syndrome (PCOS) is a complex disease linked with adverse cardiovascular, metabolic, and reproductive health outcomes. Early diagnosis of this disease in adolescence is important for treatment optimization. However, there are multiple sets of PCOS diagnostic criteria and the physiological and anatomical changes during normal pubertal development make diagnosis of adolescent PCOS difficult. Recent guidelines for PCOS in adolescents endorse the Rotterdam criteria, recommend against using ultrasound (US) imaging, and call for further investigation of potentially diagnostic biomarkers.
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