Investigation of In Vitro Drug Release from Porous Hollow Silica Nanospheres Prepared of ZnS@SiO2Core-Shell

Leila Vafayi,Soodabe Gharibe

doi:10.1155/2013/541030

Abstract

In this contribution, porous hollow silica nanoparticles using inorganic nanosized ZnS as a template were prepared. The hydrothermal method was used to synthesize pure ZnS nanospheres material. The ZnS@SiO2 core-shell nanocomposites were prepared using a simple sol-gel method successfully. The hollow silica nanostructures were achieved by selective removal of the ZnS core. The morphology, structure, and composition of the product were determined using powder X-ray diffraction (XRD), emission scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FT-IR). The results demonstrated clearly that the pure ZnS nanoparticles are in a spherical form with the average size of 40 nm and correspond with zinc blend structure. The porous hollow silica nanoparticles obtained were exploited as drug carriers to investigate in vitro release behavior of amoxicillin in simulated body fluid (SBF). UV-visible spectrometry was carried out to determine the amount of amoxicillin entrapped in the carrier. Amoxicillin release profile from porous hollow silica nanoparticles followed a three-stage pattern and indicated a delayed release effect.

Highlights

During the past decade, there have been widespread research efforts to develop architecture and fabrication of core-shell composite materials and hollow spheres of nanometer to micrometer size with special physical and chemical properties
Due to the fact that SiO2 coating semiconductor nanocrystals have an interesting field of study, they are used as bioconjugation and excellent luminescent probes [16, 17]
We reported a method for preparation of hollow silica nanospheres with porous shell structure by the sol-gel technique, using inorganic ZnS nanoparticles as a template

Summary

Introduction

There have been widespread research efforts to develop architecture and fabrication of core-shell composite materials and hollow spheres of nanometer to micrometer size with special physical and chemical properties They have demanding applications in pharmaceuticals, biology, optics, catalysts, and drug delivery [1,2,3,4,5,6,7]. Among a variety of nanoparticle-based drug delivery systems, mesoporous silica nanoparticles have several advantageous features for use in the delivery of both water soluble and insoluble drugs These materials have large surface areas and porous interiors that can be used as reservoirs for storing the drug. We reported a method for preparation of hollow silica nanospheres with porous shell structure by the sol-gel technique, using inorganic ZnS nanoparticles as a template. The porous hollow silica nanoparticles obtained were exploited as drug carriers to investigate in vitro release behavior of amoxicillin in simulated body fluid

Experimental

Results and Discussion

Conclusions