Abstract

Human bocavirus (HBoV) is a linear single-stranded DNA virus belonging to the Parvoviridae family. This study aimed to investigate the incidence of HBoV and co-infections in pediatric patients with symptoms of viral respiratory tract infection. This study included 2,310 patients between the ages of 0-18 in whom HBoV and other respiratory tract viral pathogens were analyzed in nasopharyngeal swab specimens. In the pediatric age group, HBoV was found in 4.5% (105/2310) of the patients and higher in children between the ages of 1 and 5. Mixed infection was detected in 43.8% (46/105) of HBoV positive patients (p = 0.10). Mono and mixed infection rates were higher in outpatients than in inpatients (p < 0.05). Respiratory syncytial virus was significantly higher than the other respiratory viral pathogens (p < 0.001). This study is important as it is one of the rare studies performed on the incidence of HBoV in the Marmara region. In pediatric age group, the incidence of HBoV was found 4.5%. The incidence rate of HBoV in this study was similar to those in studies around the world, but close to low rates. The incidence of HBoV was found higher especially among children between the ages of 1-5 in this study. In addition to the incidence of HBoV, accompanying co-infections in the pediatric age group were also investigated in this study. Since concurrence of RSV, HRV and hMPV with HBoV was the most common it must be considered that there may be more than one agents in patients with symptoms of respiratory tract infection.

Highlights

  • Human bocavirus (HBoV) is a linear single-stranded DNA virus belonging to the Parvoviridae family

  • Human bocavirus (HBoV) causing infection in the vertebrate is a linear single-stranded DNA virus belonging to Parvoviridae family, Parvovirinae sub-family and Bocavirus genus [3]

  • This cross-sectional study included 2,310 patients between the ages of 0-18 in whom HBoV and other respiratory tract viral pathogens were analyzed in nasopharyngeal swab specimens in Virology Laboratory between April 2015 and December 2017

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Summary

Introduction

Human bocavirus (HBoV) is a linear single-stranded DNA virus belonging to the Parvoviridae family. This study aimed to investigate the incidence of HBoV and co-infections in pediatric patients with symptoms of viral respiratory tract infection. Methodology: This study included 2,310 patients between the ages of 0-18 in whom HBoV and other respiratory tract viral pathogens were analyzed in nasopharyngeal swab specimens. The incidence of HBoV was found higher especially among children between the ages of 1-5 in this study. In addition to the incidence of HBoV, accompanying co-infections in the pediatric age group were investigated in this study. Human bocavirus (HBoV) causing infection in the vertebrate is a linear single-stranded DNA virus belonging to Parvoviridae family, Parvovirinae sub-family and Bocavirus genus [3]. HBoV accompanied by another pathogen may be detected in respiratory tract specimens at a rate of 30-50% [3,4]. It was reported in studies performed on HBoV prevalence between 2005 and 2016 that the prevalence rates ranged between 4.1-25.1% in South America, 4.1-9.8% in North America, 1.5-29.8% in Europe, 1.0-56.8% in Africa, 1.6-24.5% in the Asia, and 1.9-18.3% in the Middle East [3]

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