Investigation of heparin binding capacity of polyurethane coatings

Liza Pelyhe

doi:10.3311/pp.me.2010-2.06

Abstract

In this article the investigation of heparin binding capacity of three biocompatible polyurethane coating are shown. The polyurethanes as coating on metal carrier were studied. The heparin binding capacity has measured by Optical Waveguide Lightmode Spectroscopy (OWLS) that measure the heparin elution.I have studied which type of polyurethane coated the most heparin. The heparin binding capacity was compared of smooth, porous-free, and porous coating. The porous coating had higher heparin binding capacity than the smooth coating. Furthermore it was studied, if the heparin soaking time is increased in case of the porous coating, the heparin absorption is increased too. It was also concluded, that the increase of the time of the heparin soaking cause increase of heparin absorption.

Highlights

In the treatment of coronary diseases only the surgical intervention were considered to the 90s, but the percutaneous radiological interventions have been widespread, sparing patients from a long convalescence time and complications after cardiac surgery [1]
The sample 1 gave the lowest values, and the sample 2 gave the highest values except for the 120 minutes incubation time from the smooth coating sheets with heparin Fig. 2, Fig. 3.The sample 1 gave the lowest values, and the sample 2 gave the highest values for all three incubation times from the porous coating sheet with heparin Fig. 3
2.4 Dissolution testing The eluting heparin was measured by Optical Waveguide Lightmode Spectroscopy (OWLS).The OWLS technique is based on the measurement of the incident angle dependent photocurrent

Summary

Introduction

In the treatment of coronary diseases only the surgical intervention were considered to the 90s, but the percutaneous radiological interventions have been widespread, sparing patients from a long convalescence time and complications after cardiac surgery [1]. The drug-eluting stents reduce the incidence of restenosis [3].Different methods exist to fix the drug to the stent: drug on bare metal, drug mixed with coating, special slot with drug, drug loaded in stent reservoirs [4]. The Department of Materials Science and Engineering of BME, the Minvasive Ltd. and the Research Group for Metals Technology of HAS and BME work together on the development of stents for 15 years [13]. This group started the development of drug-eluting stents. One of the initial steps of this research is presented in this article

Methods

Results

Conclusion