Investigation of haptoglobin, serum amyloid A, and some biochemical parameters in calves with omphalitis.

K Bozukluhan,M Cihan,E E Erkilic,M Ogun,A Ozcan,O Merhan,U Aydin,G Gokce,B Kurt

doi:10.14202/vetworld.2018.1055-1058

Abstract

Aim:In this study, it was aimed to determine the concentration of some important acute phase proteins (APPs) and some biochemical parameters pre-operative and post-operative in calves with omphalitis.Materials and Methods:A total of 20 calves were used in the study and they consist of 10 clinically healthy calves that were used as a control and 10 calves with omphalitis were used as the treatment group. Blood samples were collected from Vena jugularis of animals to tubes with anticoagulant (sodium citrate) and without anticoagulants, pre-operative (day 0), and post-operative (day 7). Samples were used to determine the concentration of haptoglobin (Hp), serum amyloid A (SAA), ceruloplasmin (Cp), fibrinogen, glucose, total protein, albumin, urea, total bilirubin, creatinine, calcium, phosphorus, aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) concentrations.Results:While the Hp, SAA, Cp, fibrinogen, urea, creatinine, total bilirubin, ALP, and GGT concentrations were statistically and significantly increasing rather than the control group during the pre-operative period for calves with omphalitis, they decreased to the post-operative period. Moreover, an insignificant increase in the glucose, total protein, and AST concentrations and an insignificant decrease in the albumin, calcium, and phosphorus concentrations were statistically determined.Conclusion:We have the opinion that the assessment of biochemical parameters and especially APP levels in calves with the omphalitis together with the clinical findings may be important in terms of the treatment and prognosis.

Highlights

The umbilical tissue inflammation is a problem frequently encountered with calves by having an important place in the umbilical lesion: (i) Not cutting the umbilical cord in hygienic conditions and adequate lengths in the postnatal period, (ii) not being the shelter environment hygienic, (iii) not taking the colostrums inadequate amount, and (iv) being the pathogens present in environment may be considered between the reasons of this inflammation occurring in the umbilical tissue [1,2].The acute phase response (APR) is a non-specific reaction, shown up in a short time following the tissue damage
While the Hp, serum amyloid A (SAA), Cp, fibrinogen, urea, creatinine, total bilirubin, alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) concentrations were statistically and significantly increasing rather than the control group during the pre-operative period for calves with omphalitis, they decreased to the post-operative period
We have the opinion that the assessment of biochemical parameters and especially acute phase proteins (APPs) levels in calves with the omphalitis together with the clinical findings may be important in terms of the treatment and prognosis

Summary

Introduction

The acute phase response (APR) is a non-specific reaction, shown up in a short time following the tissue damage. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. The most important feature of APR is to cause the production of acute phase proteins (APPs) in liver [3,4]. The APPs are used to determine and diagnose the diseases, follow-up the treatment, specify the patient’s prognosis, and state the non-infectious conditions such as stress [5]. The important APPs for calves are haptoglobin (Hp), serum amyloid A (SAA), fibrinogen, and albumin [6]

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