Investigation of Graft Function-Determining Factor in Cadaveric Renal Transplantations.

Abstract

343 〈AIM〉 This study was conducted to identify the graft function -determining factors in cadaveric renal transplantations (RTx). 〈PATIENTS〉 One hundred fifty three patients treated by RTx in our center participated in this study. They were grouped by the type of donor and the mode of graft preservation as follows (HP: hypothermic continuous perfusion preservation, CS: simple cold storage): (Table)TableFor each group, multiple regression analysis was performed on donor age (D-Ag), recipient age (R-Ag), donor serum creatinine level (DS-Cr), warm ischemic time (WIT) and total ischemic time (TIT) against post-transplant graft function. 〈RESULTS〉 1) In the brain death group, even though D-Ag was significantly younger (p<0.01) and DS-Cr significantly lower (p<.01) for US kidney than for domestic kidney, ATN was significantly longer (p<.05) for US kidney, which may be attributed to a significantly longer TIT (p<.01). In domestic kidneys, ATN was significantly shorter for HP+CS group than for CS group (p<.05). 2) In the cardiac death group, even though D-Ag was significantly younger (p<.05) and DS-Cr significantly lower (p<.05) for NIS than for IS, ATN duration was significantly shorter (p<.01) for IS than for NIS. In IS cases, in spite of significantly longer WIT for HP+CS group than for CS group (p<.01), there was no difference in ATN between groups. 〈CONCLUSION〉 The function-determining factors were TIT for transplants from brain death donors and WIT for transplants from non-heart beating donors. In both the brain dead and cardiac dead groups, the presence or absence of HP was a factor for determining the graft function (whether or not the graft was treated by IS).