Abstract
Changes in the peritoneal fluid (PF) environment have been implicated in the pathogenesis of endometriosis as well as in the decrease of fertility. Objective: To evaluate the concentration of glutathione in PF of women with endometriosis. Patients: Twenty-one patients with endometriosis (I or II rAFS stage, n=11; III or IV rAFS stage, n=10), and 29 patients with follicular or dermoid ovarian cysts ( n=17 and n=12, respectively). Results: Mean (±S.D.) PF glutathione concentration was 0.22±0.01 μmol/ml in patients with minimal or mild endometriosis, 0.21±0.05 μmol/ml in women with III or IV stage of the disease, 0.24 ± 0.03 μmol/ml in women with follicle ovarian cysts, and 0.23±0.05 μmol/ml in patients with dermoid tumors of ovaries. No significant difference in the peritoneal glutathione level was found between the groups. Conclusion: These results suggest that PF glutathione is not involved in the progression of endometriosis.
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