Abstract
<p>Introduction. Chronic rhinosinusitis with sinonasal polyposis is a chronic inflammatory process of the mucous membranes of the nasal and paranasal sinuses, clinically manifested by the appearance of polyps in the nasal cavity. The presence of polyps in the nose and sinuses is the cause of the characteristic symptoms that affect the quality of life of the patient. The study investigates the correlation between endoscopic, microbiological and radiological findings and symptom severity in patients with chronic rhinosinusitis and sinonasal polyposis. Methods. The research included 45 patients with chronic rhinosinusitis and sinonasal polyps, for whom surgery treatment was indicated after the failure of conservative therapy, and 25 healthy subjects. Intensity of symptoms in subjects was assessed by A Visual Analogue Scale. The bacteriological examination of secretion of the medial nasal corridor was carried out. Clinical and radiological assessment of the severity of the condition was done by the endoscopy and computerized tomography score (CT score). Results. A statistically significant difference was found in symptom severity between the experimental and control groups. There was a statistically significant correlation between endoscopy score and the symptom severity (r = 0.315; p = 0.035), CT-score (r = 0.720; p < 0.001) and the presence of asthma (r = 0.335; p = 0.025). Furthermore, there was a statistically significant correlation between CT score and the presence of asthma (r = 0.419; p =0.004). By binary logistic regression, a statistically significant correlation between the endoscopy score and symptom severity (OR = 1.513; p = 0.044) was found. Conclusion. In comparison with the objective clinical parameters, the severity of symptoms in patients with sinonasal polyposis is in a statistically significant correlation with the endoscopy score.</p>
Highlights
Chronic rhinosinusitis with sinonasal polyposis is a chronic inflammatory process of the mucous membranes of the nasal and paranasal sinuses, clinically manifested by the appearance of polyps in the nasal cavity
Endoskopski skor je statistički značajno korelirao sa težinom simptoma (r = 0,315; p = 0,035), CT-skorom (r = 0,720; p < 0,001) i prisustvom astme (r = 0,335; p = 0,025))
Studije koje su ispitivale korelaciju između subjektivnih i objektivnih kliničkih parametara kod pacijenata sa Hronični rinosinuzitis (HRS) sa nosnosinusnom polipozom nisu utvrdile značajnu povezanost ili su samo utvrdile povezanost pojedinačnih parametara [4, 5]
Summary
U ovoj studiji je ispitana povezanost između endoskopskog, mikrobiološkog, radiološkog nalaza i težine simptoma pacijenata sa hroničnim rinosinuzitisom i nosnosinusnom polipozom. Istraživanjem je obuhvaćeno 45 pacijenata sa hroničnim rinosinuzitisom i nosnosinusnom polipozom, kod kojih je indikovano operativno liječenje nakon neuspjeha konzervativne terapije i 25 ispitanika kontrolne grupe. Endoskopski skor je statistički značajno korelirao sa težinom simptoma (r = 0,315; p = 0,035), CT-skorom (r = 0,720; p < 0,001) i prisustvom astme (r = 0,335; p = 0,025)). Binarnom logističkom regresijom smo utvrdili statistički značajnu povezanost između endoskopskog skora i težine simptoma (OR = 1,513; p = 0,044). U odnosu na objektivne kliničke parametre, težina simptoma kod pacijenata sa nosnosinusnom polipozom statistički značajno korelira sa endoskopskim skorom. Ispitivanje potencijalnih etiopatogenetskih faktora HRS još predstavlja aktuelnu temu s obzirom na multifaktorske mehanizme nastanka oboljenja. Generalno je prihvaćena podjela HRS na HRS sa nosnosinusnom polipozom i HRS bez nosnosinusne polipoze [1]
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