Abstract
Purpose: The size of polymeric nanoparticles is considered as an effective factor in cancer therapy due to enterance into tumor tissue via the EPR effect. The purpose of this work was to investigate the effective parameters on poly(lactic-co-glycolic acid)-paclitaxel (PLGA –PTX) nanoparticles size.Methods: We prepared PLGA-PTX nanoparticles via single emulsion and precipitation methods with variable paremeters including drug concentration, aqueous to organic phase volume ratio, polymer concentration, sonication time and PVA concentration.Results: PLGA-PTX nanoparticles were characterized by dynamic light scattering (DLS) and scanning electron microscopy (SEM). The results exhibited that the diameter of nanoparticles enhanced with increasing drug, polymer and PVA concentrations whereas organic to aqueous phase volume ratio and sonication time required to the optimization for a given size.Conclusion: The precipitation method provides smaller nanoparticles compared to emulsion one. Variable parameters including drug concentration, aqueous to organic phase volume ratio, polymer concentration, sonication time and PVA concentration affect diameter of nanoparticles.
Highlights
Cancer is a major global cause of morbidity and mortality which is estimated that the incidence of all new cancer cases will reach 22 million by 2030 in worldwide.[1]
We investigated the effect of two methods of single emulsion and precipitation on nanoparticles size
The size of polymeric nanoparticles is important in cancer therapy as drug delivery vehicles can enter into the tumor tissue via the enhanced permeability and retention (EPR) effect
Summary
Cancer is a major global cause of morbidity and mortality which is estimated that the incidence of all new cancer cases will reach 22 million by 2030 in worldwide.[1]. The absence of lymphatic drainage in tumors leads to retention of accumulated therapeutic agents within the tumor tissue.[11,12] This unusual extravasation, accumulation and retention of expediently sized therapeutic molecules within tumor tissue is called enhanced permeability and retention (EPR) effect.[13] In addition, nano-sized drug carriers can simultaneously deliver higher amounts of drugs with lower unspecific toxicity, without loss in therapeutic activity. A wide range of synthetic and natural polymers have been investigated for a variety of biomedical applications such as tissue engineering,[23,24]
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