Abstract
The effect of endotoxin and cortisone treatment on the mesangial handling of ferritin in rats was examined. Experimental conditions were chosen where the RES was saturated, this enabled us to test for a direct effect on the mesangium. We were unable to detect any influence of either endotoxin or cortisone on the degree of uptake, or the rate of elimination of ferritin from the mesangium. Endotoxin did appear to affect the intra-glomerular distribution of ferritin, which was seen mainly as larger nodules. The iron core of ferritin was found to persist for longer than the antigenic (protein) portion, indicating that some degree of breakdown of ferritin molecules occured within the mesangium.
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