Investigation of dysfunctional HDL using myeloperoxidase / paraoxonase ratio in lymphoma

Abstract

Background: The aim of this study is to investigate the myeloperoxidase/paraoxonase ratio which indicates dysfunction of high-density lipoprotein in various types of lymphoma characterized by abnormal lipid metabolism, oxidative stress, and inflammation. Methods: Thirty lymphoma patients and 30 healthy subjects were enrolled in this study. Serum myeloperoxidase, paraoxonase, arylesterase, lipid hydroperoxide and routine biochemistry tests levels were measured on an automated analyzer. The diagnosis of lymphoma patients was made according to the histological examination of the biopsy material. Results: Compared with healthy control group; the albumin, arylesterase, high-density lipoprotein, thiol, and Hemoglobin levels were significantly lower while myeloperoxidase / paraoxonase, myeloperoxidase/arylesterase, and lipid hydroperoxide levels were significantly higher, in patients with lymphoma. Also, lipid hydroperoxide level was significantly correlated with myeloperoxidase / paraoxonase and myeloperoxidase / arylesterase (r= 0.330, p=0.046; r= 0.588, p< 0.001, respectively). Conclusions: We think that dysfunctional high-density lipoprotein is an important factor in the inflammatory process, atherosclerosis, oxidative stress, and impaired lipid metabolism that can be observed in patients with lymphoma. We believe that in the future the myeloperoxidase/paraoxonase ratio can be used as a treatment criterion to prevent diseases that cause dysfunctional high-density lipoprotein.