Abstract
The aim of the present study was tochecked the compatibility between drug: lipid and drug: excipients. Ellagic acid was selected as model drug while phospholipid and Cholesterol were considered excipients. The study was performed by Fourier transform infrared spectroscopy (FTIR), Diffraction scanning calorimetric (DSC) and High performance liquid chromatography (HPLC). The spectrophotometric graphs revealed that there was no significant changes in the position of functional groups of ellagic acid, phospholipid and Cholesterol (O-H, C=O, C-H str.) in pure drugs and excipients with respect to their physical mixtures. Further the samples werecharacterized by using DSC and HPLC methods and found no any interaction between drug excipients. Combination of synthetic herbal drug and pharmaceutical excipients are compatible with each other and shows no interaction. Thus this suitable combination can be employed for the successful development of novel liposomal carrier system.
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