Abstract
AbstractIn this study, DNA‐binding activities of previously synthesized tetrakis(3,4,5‐trimethoxybenzyloxy)‐substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) have been chosen for the study. The interaction of synthesized tetrakis(3,4,5‐trimethoxybenzyloxy)‐substituted Zn(II) and Co(II) phthalocyanine compounds with CT‐DNA was investigated by using UV/Vis titrimetric method, fluorescence spectroscopy, cyclic voltammetry, thermal denaturation profile, gel electrophoresis and viscosty measurement in a Tris‐HCI buffer at pH 7.0. The results indicated that tetrakis(3,4,5‐trimethoxybenzyloxy)‐substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) can interact with CT‐DNA via intercalation binding mode.
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