Abstract
Pathogenesis of reactive arthritis (ReA) is not clear yet. Several trials suggest that increased production of proinflammatory cytokines is responsible for development of arthritis in ReA, while other studies report that Th1 cytokine response in ReA is impaired in favor of Th2 response. The aim of our study was to investigate serum levels of cytokines IL-1β, IL-4, IL-6, TNFα, IFNγ and IL-1Ra in the patients with ReA of different etiology, as compared with infection-related arthritis. The results of our study had demonstrated that serum levels of IL-1β and TNFα in the patients with ReA were significantly higher, whereas IL-1Ra, IL-4, IL-6 proved to be significantly lower than in healthy controls. Serum levels of IL-6 were significantly higher in patients with chronic ReA, as compared to the cases of acute and recurrent ReA. No significant differences in cytokine profiles were found between the patients with ReA, and the persons with infection-related arthritis. The data obtained are, generally, suggestive for proinflammatory Th1 cytokine profile in ReA patients studied, this confirming the mostly assumed pathogenetic hypothesis for reactive arthritis where an underlying cytokine imbalance is suggested. (Med. Immunol., 2008, vol. 10, N 2-3, pp 167-172).
Highlights
Общепринятых диагностических критериев реактивного артрита (РеА) не существует [3, 10]
No significant differences in cytokine profiles were found between the patients with reactive arthritis (ReA), and the persons with infection-related arthritis
Van der Bosch F., Kruithof E., Beaten D., Herssens A., Keyser F., Mielants H., Veys E.M. Randomized double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor α (Infliximab) versus placebo in active spondyloarthropathy // Arthritis Rheum
Summary
Целью нашей работы явилось изучение уровней IL-1β, IL-4, IL-6, TNFα, IFNγ и IL-1Ra в сыворотке крови у больных РеА различной этиологии в сравнении с артритами, связанными с инфекцией. The aim of our study was to investigate serum levels of cytokines IL-1β, IL-4, IL-6, TNFα, IFNγ and IL-1Ra in the patients with ReA of different etiology, as compared with infection-related arthritis. Часть авторов склоняется к мнению, что при РеА антибактериальный Тh1-иммунный ответ (продукция IFNγ, TNFα, IL-2 и IL-12) снижен в пользу Th2-иммунного ответа (синтез IL-4 и IL-10) [4, 6], другие исследователи указывают на провоспалительный цитокиновый профиль при РеА [12, 14]. Целью настоящей работы явилось изучение содержания IL-1β, IL-4, IL-6, TNFα, IFNγ и IL-1Ra в сыворотке крови у больных РеА различной этиологии в сравнении с артритами, связанными с инфекцией
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