Abstract
The ability of three cytostatic alkylating agents to form cross-links with DNA has been investigated by renaturation experiments. Two of them, IMET 3943 and 3106, are effective in renaturing DNA in vitro after treatment in Tris buffer solution. The relative high bifunctional alkylation tendency found for IMET 3106 can be attributed to its cancerostatic active degradation product N,N- bis(β- chloroethyl)-p- phenylenediamine .
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis
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