Abstract
Isothermal titration calorimetry (ITC) and potentiometric titration methods have been used to study the process of proton transfer in the copper(II) ion-gly- cylglycine reaction. The stoichiometry, conditional stabil- ity constants, and thermodynamic parameters (DG, DH, and DS) for the complexation reaction were determined using the ITC method. The measurements were carried out at 298.15 K in solutions with a pH of 6 and the ionic strength maintained with 100 mM NaClO4. Carrying out the measurements in buffer solutions of equal pH but dif- ferent enthalpies of ionization of its components (Mes, Pipes, Cacodylate) enabled determination of the enthalpy of complex formation, independent of the enthalpy of buffer ionization. The number of protons released by gly- cylglycine on account of complexation of the copper(II) ions was determined from calorimetric and potentiometric measurements.
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