Abstract
Background: Over-expression of Epidermal Growth Factor (EGF) and hypoxia are features of colorectal cancer (CRC), thus the development of novel treatments targeting EGF and its receptors, such as cetuximab. Recent studies uncovered a pro-angiogenic role for EGF but involvement by Vascular Endothelial Growth Factor (VEGF) is unknown. Moreover, it is unknown whether EGF can synergise with hypoxia in CRC. Aim of the study was to investigate the pro-angiogenic effect induced by EGF in combination with hypoxia in CRC.
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Schedule a callMore From: Clinical oncology (Royal College of Radiologists (Great Britain))
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