Abstract
Phagocytosis, the process in which phagocytes clear pathogens and apoptotic cells is an important part of our innate immune defense. After cell-target binding and subsequent target detection by receptors in the membrane, the formation of the phagocytic cup around the target is driven by the polymerization of cortical actin. While the main proteins involved in phagosome formation have already been identified, a full model of the uptake process has not been developed yet, in part because mechanical aspects such as the early binding kinetics and the cortical rheology during the process remain largely elusive.
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