Investigation of clinical and genetic factors in patients with deep vein thrombosis. A retrospective study

Abstract

Introduction: Generally, risk factors for deep vein thrombosis (DVT) include advanced age, surgery, fractures, pregnancy, puerperium, use of oral contraceptives, hormone replacement therapy, cancer and genetics associated with the hemostatic system in influencing thrombotic risk. The aim of this study was to evaluate routine complete blood count parameters, the clinical and genetic data of patients with diagnosis of DVT in our hospital and to contribute to the literature with our results. Material and methods: This retrospective study included a total of 152 patients (67 males and 85 females) diagnosed with DVT between January 2016 and September 2019. The history, clinical findings, venous doppler ultrasonography and genetic analysis results of patients were evaluated. Results: The study included 152 DVT patients. When the lower extremity venous doppler ultrasonography (VDU) results were evaluated, venous insufficiency was detected in 126 patients (82.9%), 57 of whom were male and 69 were female. Genetic results of F2 G20210A, FVL G1691A, MTHFR C677T and MTHFR A1298C were examined. FLV gene distributions were statistically different between genders (38.8% of men; 16.5% of women). This difference was also statistically significant (p = 0.003). Conclusion: The hemogram parameters were found to be insufficient markers. VDU was seen to be a clinically necessary marker in diagnosis; and genetic outcomes were important in initiating appropriate treatment in the early period. These results also show that there are differences according to gender in determining thrombotic risk.