Investigation of certain varieties of carbopol in ketorolac tromethamine hydrophilic matrix tablet formulations and evaluation of the kinetics of its in vitm release

Lütfı Genç ,Hegazy Nahed,Betül Arıca

doi:10.3797/scipharm.aut-02-20

Lütfı Genç , Hegazy Nahed + Show 1 more

Open Access

https://doi.org/10.3797/scipharm.aut-02-20

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Abstract

Matrix tablets of ketorolac trometharnine (KT) were prepared by direct compression technique and Carbopol 934, 940 and 1342 have been used as polymers in different concentrations (5-15 % ). For the quality control of tablets; physical tests as crushing strength, diameter-height ratio and fkiability, KT amount assay and in vitro dissolution techniques were performed and dissolution profiles were plotted and evaluated kinetically. The in vitro release kinetics of ten different formulations of KT matrix tablet were studied at pH 1.2 and pH 7.0 using the USP dissolution technique and apparatus with basket assembly. Dissolution results were evaluated kinetically and statistically. According to our results, different types and concentrations of carbopol to tablet formulations may effect in controlled drug release.

Highlights

IntroductionWhen designing an oral sustained release formulation, the hydrophilic matrices present an alternative to other pharmaceutical dosage forms
Hydrophilic matrices became extremely popular in controlling the release of drugs
The in vitro release profiles obtained from the ketorolac trometharnine (KT) matrix tablet formulations were fitted to the main models which have been proposed to describe drug release kinetics from tablets and other polymer matrices

Summary

Introduction

When designing an oral sustained release formulation, the hydrophilic matrices present an alternative to other pharmaceutical dosage forms. Three different sustained release agents, i.e., Compritol 888 (glyceryl behenate), Klucel HXF (hydroxypropylcellulose) and Carbopol 934 P (carbomer) had been used to prepare theophylline tablets with a desired release rate of approximately 50% in 6h by El-Sayed et a1.(6). The release profiles of glyceryl behenate tablets were best described by the linear square root of time dependence, indicating a diffusion controlled mechanism They studied that comparative bioavailability of theophylline tablets with different sustained release kinetics in their second study (7). The sustained release agents were Compritol, glyceryl behenate, Klucel HXF, hydroxypropyl cellulose, and carbopol 934 These polymers containing tablets provided much slower drug release in vivo than the respective control tablets. The effect of polymer types and their concentrations on release behaviour and physical properties of matrix tablets were investigated

Materials

Evaluation of release kinetics

Results and Discussion

Conclusion