Investigation of catalytic activity of solid acidic Fecl3/bentonite catalyst on the synthesis of some (E)-1-(2,4-dimethylthiazol-5-yl)-3-phenylprop-2-en-1-ones by solvent-free technique

Abstract

Abstract In this work, an attempt was made to synthesized more than 90% yields of (E)-1-(2,4-dimethylthiazol-5-yl)-3-phenylprop-2-en-1-one by cross-aldol condensation reaction of 5′acetyl 2,4-dimethylthiazole with various substituted benzaldehydes in the presence solid acidic FeCl3/Bentonite catalyst using microwave irradiation under solvent-free conditions. The synthesized (E)-1-(2,4-dimethylthiazol-5-yl)-3-phenylprop-2-en-1-one derivative was characterized by physical constants, UV, FT-IR, 1H NMR and 13C NMR spectral data. In this condensation, the effect of catalytic activity was investigated by the obtained yield of enones and reusability. This greener technique offered for high yield of 2,4-dimethylthiazole enones.