Abstract
Several highly modular chiral amino diol tridentate ligands were found to be effective for the asymmetric alkylation reaction of aromatic aldehydes in the presence of methyllithium reagent, providing up to 96% ee values and up to 94% yields under relatively mild conditions. The investigation of the catalytic activity of these ligands shows a correlation of enantioselectivities of ligands with steric properties of substituent N-alkyl and nucleophilic Li-alkyl. With the addition of Ti(O-i-Pr)4 to the ligand 3c, the 1H NMR spectrum reveals a hexa-coordinate Ti transition state complex with only one Ti metal center generated in solution.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.