Investigation of brain-heart network during sleep.

Abstract

Interactions between brain and heart play an important role for sleep quality and control. However, the influence mechanism was still unclear. This study aimed to further investigate this mechanism according to build an information transfer network of brain-heart coupling. This study included 24 healthy individuals and both of them underwent overnight polysomnography. The relative spectral powers of five frequency bands and the high frequency power of heart rate variability were extracted from six electroencephalogram (EEG) channels and electrocardiography (ECG) respectively. For each EEG channel, brain-heart interaction networks were built and a directionality analysis was conducted by using multivariate transfer entropy. Results revealed the bidirectionality of information transfer between brain and heart during sleep, and the information was dominantly transfer from heart to brain. The information transfer strength between brain and heart were significantly stronger than which between frequency bands in each EEG channels. Besides, the frequency bands and EEG channels had evident influence on these interactions. This study exposed more detailed characteristics of brain-heart interaction, which will facilitate the future study about the sleep control and the diagnose of sleep related disease.