Investigation of BPA Toxicity in Male New Zealand White Rabbits

Abstract

The current study investigated bisphenol A (BPA) toxicity in rabbits. After the adaptation period of 2 weeks, 24 male New Zealand rabbits were equally assigned to 4 treatment groups. Corn oil was given to the rabbits in the control group, whereas 10, 20, or 100 mg/kg daily BPA in corn oil was administered to the rabbits in the remaining groups orally for 9 weeks. Throughout the experiment, BPA did not cause any clinical symptoms, and serum BPA levels of the rabbits treated with BPA were elevated in a dose-dependent manner. Although no effects of BPA were apparent on feed intake, body weights, or organ weights, BPA altered MDA, CAT, SOD, and GPx levels in all organs examined. Furthermore, BPA treatments negatively affected red blood cell counts, hemoglobin, and serum ALP, AST, ALT, CRP, amylase, creatine, and urea concentrations. The present study concluded that the LOAEL dose of BPA for the hematological and biochemical parameters was 20 mg/kg/day.