Abstract
Purpose To investigate the characteristics of blood in nonsyndromic retinitis pigmentosa (RP) and reveal the pathogenesis of blood cells involved in blood stasis in RP. Design This is a retrospective observational study. Methods We collected vein blood from 101 cases of patients with nonsyndromic RP and 120 cases of normal individuals according to a single-blind study and used routine clinical examination to detect the indicators of blood. All the subjects were mainly from the central south of China. Data were analyzed statistically between the RP group and normal control. Results The indicator of platelet distribution width (PDW) in patients with RP was higher than that in the normal group; the indicators of red blood cell (RBCs), hemoglobin (HGB), hematocrit (HCT), basophils (BASs), platelets (PLTs), and plateletcrit (PCT) in the RP group were lower than those in the normal control. The differences were statistically very significant between the RP group and normal group (p < 0.01). There were no statistical differences in the other indicators between the RP and normal group. Conclusions The changes in RBCs and PLTs in patients with RP implied that RP induces RBC aggregation and platelet activation, leading to blood stasis which in turn initiates more apoptosis.
Highlights
Retinitis pigmentosa (RP) is a group of heterogeneous inherited retinal degeneration disease [1]
E abnormal blood flows in RP have received considerable attention in recent years, and the findings suggest that attenuation of retinal vessels and decreased blood flow lead to blood stasis in retinal circulation [3,4,5,6]. e blood stasis leads to decreased oxygen and material supply which cannot meet consumption for photoreceptor cascade, and photoreceptor death occurs [7]
Comparison of red blood cells (RBCs) Indicators between the Normal and RP Group. e indicators of RBCs, HGB, HCT, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and RDW-cv both in the RP group and normal control were in accordance with the normal distribution
Summary
Retinitis pigmentosa (RP) is a group of heterogeneous inherited retinal degeneration disease [1]. E abnormal blood flows in RP have received considerable attention in recent years, and the findings suggest that attenuation of retinal vessels and decreased blood flow lead to blood stasis in retinal circulation [3,4,5,6]. E blood stasis leads to decreased oxygen and material supply which cannot meet consumption for photoreceptor cascade, and photoreceptor death occurs [7]. The relationship between the characteristics of blood indicators and the pathogenesis of abnormal blood flow in RP is still unclear; understanding the underlying mechanism may help in clinical prevention and treatment of this disease. We retrospectively analyzed the indicators in clinical routine examination of Journal of Ophthalmology blood of the nonsyndromic RP patients and normal individuals as control, characterized the blood in nonsyndromic RP, and provided a reference for research of blood flow in RP
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